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Molecular Pathology,

Edition 3 The Molecular Basis of Human Disease

Editors: Edited by Gregory J. Tsongalis, PhD, HCLD, CC, FNACB and William B. Coleman

Publication Date: 01 Dec 2026

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Molecular Pathology: The Molecular Basis of Human Disease, Third Edition is a comprehensive reference that explores the molecular mechanisms and basis of major human diseases. Expertly crafted, this book is designed for use as a teaching tool for medical students, biomedical graduate students, and allied health students. It serves as an advanced resource for pathology residents, postdoctoral fellows, basic scientists, and physician scientists engaged in disease-related research, presenting traditional pathology in the context of translational molecular medicine. In this new edition, the chapters have been fully updated and rearranged for better logical flow.

Notably, four new chapters have been included, covering topics such as the pathogenesis of fibrotic diseases, mechanisms of mutation, molecular basis of soft tissue disease and pathology, and pathogenesis and pathophysiology. The book remains an invaluable reference for anyone seeking a deeper understanding of the molecular aspects of human disease.

Key Features

Presents new chapters on the Pathogenesis of Fibrotic Diseases and Mechanisms of Mutation and the Molecular Basis of Soft Tissue Diseases, Pathology, Pathogenesis, and Pathophysiology, and more
Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease
Explains the practice of "molecular medicine" and the translational aspects of molecular pathology

About the author

Edited by Gregory J. Tsongalis, PhD, HCLD, CC, FNACB, Laboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth, Hitchcock Medical Center and Dartmouth Cancer Center, Lebanon, NH, United States and the Geisel School of Medicine at Dartmouth, Hanover, NH, USA and William B. Coleman, Executive Officer, American Society for Investigative Pathology, Rockville, MD, USA

1. Pathology, Pathogenesis, and Pathophysiology: An Introduction to Disease
2. Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease
3. Molecular Mechanisms of Cell Death
4. Acute and Chronic Inflammation Induces Disease Pathogenesis
5. Infection and Host Response
6. Neoplasia
7. Pathogenesis of Fibrotic Diseases
8. (old Chapter 5) Basic Concepts in Human Molecular Genetics
9. Mechanisms of Mutation
10. The Human Genome: Implications for the Understanding of Human Disease
11. The Human Transcriptome: Implications for the Understanding of Human Disease
12. The Human Epigenome: Implications for the Understanding of Human Disease
13. Clinical Proteomics and Molecular Pathology
14. Integration of Molecular and Cellular Pathogenesis: A Bioinformatics Approach
15. Molecular Basis of Cardiovascular Disease
16. Molecular Basis of Hemostatic and Thrombotic Diseases
17. Molecular Basis of Lymphoid and Myeloid Diseases
18. Molecular Basis of Diseases of Immunity
19. Molecular Basis of Pulmonary Disease
20. Molecular Basis of Diseases of the Gastrointestinal Tract
21. Molecular Basis of Liver Disease
22. Molecular Basis of Diseases of the Exocrine Pancreas
23. Molecular Basis of Diseases of the Endocrine System
24. Molecular Basis of Gynecologic Diseases
25. Molecular Pathogenesis of Kidney Diseases
26. Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations
27. Molecular Biology of Breast Cancer
28. Molecular Basis of Skin Disease
29. Molecular Pathogenesis of Diseases of the Eye
30. Molecular Basis of Bone Diseases
31. Molecular Basis of Soft Tissue Diseases
32. Molecular Basis of Diseases of the Nervous System
33. Molecular Diagnosis of Human Disease
34. Molecular Assessment of Human Disease in the Clinical Laboratory
35. Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

Molecular Pathology,

Editors: Edited by Gregory J. Tsongalis, PhD, HCLD, CC, FNACB and William B. Coleman

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About the author

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