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Diagnostic Molecular Biology,

Edition 2

Editors: By Chang-Hui Shen

Publication Date: 29 Jun 2023

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Diagnostic Molecular Biology, Second Edition provides an up-to-date comprehensive overview of the latest advances in molecular diagnostics and the fundamental molecular aspects in this area. The book delves into the essential principles behind the transmission and expression of genetic information, including nucleic acids, proteins, and chromosomes, specifically their genome structure, life cycle, and evolution. The latest methods and instrumentation in the field are examined with detailed procedures and explanations provided for each technique. A range of techniques are also investigated, such as those used in sequencing analysis, genome and transcriptome analysis, and nucleic acid amplitification techniques. This book covers the collection, isolation, and purification of DNA, RNA, and protein from different sources. Additionally, discussion on the applications of next-generation sequencing (NGS) and the role of NGS in the future of precision medicine is included. The book also examines the use of molecular diagnostics for chromosomal disorders, inherited diseases, and infectious diseases. Moreover, this new edition features recent advances in the detection of respiratory virus infections in humans, including that of SARS-CoV2. Diagnostic Molecular Biology, Second Edition, is an ideal reference for researchers, lab technicians, and students in medical laboratory science, molecular biology, microbiology, virology, and related fields.

Key Features

Provides explanations on how techniques are used to diagnosis at the molecular level
Explains how to use information technology to communicate and assess results in the lab
Enhances our understanding of fundamental molecular biology and places techniques in context
Places protocols into context with practical applications
Includes extra chapters on respiratory viruses (Corona)

About the author

By Chang-Hui Shen, Professor of Biology and Chair of the Biology Department at the College of Staten Island, City University of New York, New York, USA

1. Nucleic Acids: DNA and RNA 2. Nucleic Acid-Based Cellular Activities - DNA Replication, Damage, and Repair 3. Gene Expression: Transcription of the Genetic Code 4. Gene Expression: Translation of the Genetic Code 5. The Genome 6. Extraction and Purification of Nucleic Acids 7. Quantification and Analysis of Nucleic Acids 8. Extraction and Purification of Proteins 9. Quantification and Analysis of Proteins 10. Amplification of Nucleic Acids 11. Characterization of Nucleic Acids and Proteins 12. Techniques in Sequencing 13. Genome and Transriptome Analysis 14. Molecular Diagnosis of Chromosomal Disorders 15. Molecular Diagnosis of Gene Mutation and Inherited Diseases 16. Molecular Diagnosis of Infectious Diseases 17. The Biology of SARS-CoV-2 and the Molecular Diagnosis of COVID-19 18. Guidance for Molecular Diagnostic Laboratory

Book Reviews

“…provides a comprehensive overview of the updated information on current advances in molecular biology…. [with] illustrations which enable easy understanding of the complex subject. The purpose of the second edition of this book is to help health professionals accurately identify the cause of diseases and to provide students with insights into key advances in the field of molecular diagnosis…. The book provides detailed coverage on the principles and applications of sequencing techniques, current molecular techniques in identifying diseases, and covers the function of molecular cytogenetic diagnosis in chromosomal disorders and the molecular diagnosis of genetic diseases…. [and] has several high-quality colored illustrations which facilitate a clearer comprehension of a complex subject matter…. [U]nique as it very nicely covers the recent advances in the detection of respiratory syncytial virus infections including SARS-CoV-2 which caused the COVID-19 pandemic.¿ —©Doody’s Review Service, 2024, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)

ISBN: 9780323917889

Page Count: 588

Retail Price :

9780128160619; 9780128029718; 978-0-12-813679-9

researchers and technicians in the lab, pathologists, and students in molecular biology, microbiology and virology clinical laboratory scientists and technicians