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Toxicoepigenetics,

Edition 1 Core Principles and Applications

Editors: Edited by Shaun D. McCullough and Dana Dolinoy

Publication Date: 07 Nov 2018

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Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study.

Key Features

Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology
Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds
Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

About the author

Edited by Shaun D. McCullough, Principal Investigator - National Health and Environmental Effects Research Laboratory, Clinical Research Branch, United States Environmental Protection Agency, Chapel Hill, NC, USA and Dana Dolinoy, NSF International Chair of Environmental Health Sciences, Professor of Environmental Health Sciences & Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA

Prelude

Introduction to the Role of the Epigenome in Health and Disease

Section 1

1. The Role of Histone Acetylation and Acetyltransferases in Gene Regulation

2. The Role of Histone Methylation and Methyltransferases in Gene Regulation

3. Linking Chromatin Accessibility with Exposure Effects and Susceptibility

4. Implications for Chromatin Biology in Toxicology

Section 2

5. The Role of DNA Methylation in Gene Regulation

6. Implications of DNA Methylation in Toxicology

7. DNA Methylation as a Biomarker in Environmental Epidemiology

8. DNA Hydroxymethylation: Implications for Toxicology and Epigenetic Epidemiology

Section 3

9. The Role of Non-Coding RNAs in Gene Regulation

10. miRNAs and lncRNAs as Biomarkers of Toxicant Exposure

Section 4

11. Germline and Trans-generational Impacts of Toxicant Exposures

12. Novel Bioinformatics Methods for Toxicoepigenetics

13. Incorporating Epigenetics into Risk Assessment Frameworks

Section 5

14. Chromatin Immunoprecipitation: General Protocol and Considerations for Analysis

15. Methods for Analysis of DNA Methylation

16. Methods for Analyzing miRNA Expression

ISBN: 9780128124338

Page Count: 428

Retail Price :

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Researchers, academics, and advanced students and in toxicology and related fields. Investigators, risk assessors and regulators in academia, industry and government.