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Canine and Feline Cytopathology,

Edition 4 A Color Atlas and Interpretation Guide

Editors: By Rose E. Raskin, DVM, PhD, DACVP, Denny Meyer, DVM, DACVIM, DACVP and Katie. M Boes

Publication Date: 25 Mar 2022

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Canine and Feline Cytopathology: A Color Atlas and Interpretation Guide, 4th Edition provides a comprehensive overview of diagnostic cytopathology for companion animals, covering all body systems and fluids. Rapidly resolve diagnostic challenges with this guide to specimen collection and evaluation, featuring more than 2,400 photomicrographs that show cytology of normal structures to contrast and support identification of cytopathology of inflammatory, hyperplastic, and neoplastic lesions. Enhancements to this edition include hundreds of new images with crisper quality and truer colors; new chapters on the pancreas and ear; updated, contemporaneously referenced information for all chapters; expanded listing for neoplastic and infectious disease testing, quality assurance, and reporting; and access to a fully searchable enhanced eBook with new print purchase. Written by seasoned veterinary cytopathologists and award-winning educators Rose Raskin, Denny Meyer, and Katie Boes, with contributions from 20 international experts, this reference offers clear, practical guidelines to sampling procedures, slide preparation, and interpretation leading to diagnoses and/or classification of the cytopathologic findings. Anticipate the expected and expect the unexpected with this atlas, which vividly illustrates the expected cytologic elements associated with the organ system and provides abundant examples of unexpected cytopathologic findings.

Key Features

Comprehensive coverage of all body systems and body fluids emphasizes the application of aspirate biopsy cytopathology for greatest diagnostic impact
Exceptional-quality, full-color photomicrographs include detailed figure legends
Helpful hints for improving specimen quality are provided in discussions of common errors and problems, resulting in more diagnostically effective, cost-effective use of cytopathology
Discussions of clinical findings, differential diagnostic considerations, and the rationale are included for the final cytopathological diagnosis
Additional photomicrographs in organ system chapters demonstrate the histological or histopathologic corollary of cytopathologic findings
Easy-to-use, well-organized format includes many tables, algorithms, boxes, and Key Point callouts for at-a-glance reference
Clear, concise descriptions include sampling techniques, slide preparation and examination, and guidelines for interpretation, leading to accurate in-house and commercial laboratory diagnosis
Extensively revised organ system-based chapters include focused contemporary references

New Features

NEW! 700 crisp, all-new images more closely match the colors representative of the actual microscopic view
NEW! Expanded content combines coverage of the exocrine and endocrine pancreas and adds a new emphasis on the ear, specifically otic sample collection and cytopathology
NEW! All-new appendices provide quick reference to infectious agents, immunocytochemistry, reporting, molecular and immunologic testing, quality assurance, and more
NEW! Enhanced eBook is included with each new print purchase, providing access to a fully searchable text online — available on a variety of devices

About the author

By Rose E. Raskin, DVM, PhD, DACVP, Professor of Veterinary Clinical Pathology, Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana; Denny Meyer, DVM, DACVIM, DACVP, Executive Director, Navigator Services, Charles River Preclinical Services, Reno, NV and Katie. M Boes

1. Simple Acquisition and Management of Cytology Specimens
A. General Sampling Guideline
B. Diagnostic Imaging-Guided Sample Collection
C. Managing the Cytologic Specimen
D. Staining the Specimen
E. Site-Specific Considerations
F. Submitting Cytology Specimens to a Reference Laboratory
G. References

2. General Categories of Cytologic Interpretation
A. Normal Tissue
B. Hyperplastic Tissue
C. Cystic Mass
D. Inflammation or Cellular Infiltrate
E. Response to Tissue Injury
F. Neoplasia
G. Artefacts and Other Questionable Findings
H. References

3. Skin and Subcutaneous Tissues
A. Normal Histology and Cytology
B. Normal-Appearing Epithelium
C. Noninfectious Inflammation
D. Infectious Inflammation
E. Parasitic Infestation
F. Epithelial Morphology Neoplasia
G. Mesenchymal Morphology Neoplasia
H. Round or Discrete Cell Morphology Neoplasia
I. Naked Nuclei Morphology Neoplasia
J. Response to Tissue Injury
K. References

4. Hemolymphatic System
A. General Cytodiagnostic Groups for Lymphoid Organ Cytology
B. Lymph Nodes
C. Spleen
D. Thymus
E. Extramedullary Hematopoiesis
F. References

5. Respiratory Tract
A. The Nasal Cavity
B. Larynx
C. Trachea, Bronchi, and Lungs
D. References

6. Body Cavity Effusions
A. Collection Techniques
B. Sample Handling
C. Laboratory Evaluation
D. Normal Cytology and Hyperplasia
E. General Classification of Effusions
F. Specific Inflammatory Types of Effusions
G. Bilious Effusion
H. Chylous Effusion
I. Neoplastic Effusion
J. Hemorrhagic Effusion
K. Parasitic Effusion
L. Pericardial Effusions
M. Miscellaneous Effusion Findings
N. Ancillary Tests
O. References

7. Oral Cavity, Gastrointestinal Tract, and Associated Structures
A. Oral Cavity
B. Salivary Gland
C. Esophagus
D. Criteria for Gastrointestinal Cytology
E. Stomach
F. Intestine
G. Colon/Rectum
H. References

8. Fecal Cytology
A. Sample Collection and Processing
B. Normal or Incidental Microscopic Findings
C. Abnormal Microscopic Findings
D. References

9. Pancreas (Exocrine/Endocrine)
A. Normal Cytology
B. Hyperplasia
C. Inflammation
D. Neoplasia
E. Ancillary Tests
F. References

10. Liver and Gall Bladder
A. Sampling the Liver
B. Normal Liver Cytology
C. Normal Gallbladder Cytology
D. Non-Neoplastic Diseases and Disorders
E. Neoplasia
F. References

11. Urinary Tract
A. Normal Anatomy and Histology
B. Specialized Collection Techniques
C. Normal Renal Cytology
D. Non-Neoplastic and Benign Lesions of the Urinary Tract
E. Neoplasia
F. References

12. Microscopic Examination of the Urinary Sediment
A. Sediment Preparation
B. Microscopic Examination and Recording
C. References

13. Reproductive System
A. Mammary Glands
B. Ovaries
C. Uterus
D. Vagina
E. Prostate Gland
F. Testes
G. References

14. Musculoskeletal System
A. Normal Joint Anatomy and Synovial Fluid Production
B. Synovial Fluid Evaluation
C. Normal Gallbladder Cytology
D. Musculoskeletal Disorders
E. References

15. The Central Nervous System
A. Cerebrospinal Fluid
B. Cytology of Nervous System Tissue
C. Newer Diagnostic Tools and Recent Studies
D. References

16. Ocular and Otic Sensory Systems
A. General Cytodiagnostic Groups for Ocular Cytology
B. Cytologic Biopsy Considerations for the Eye and Adnexa
C. Eyelids
D. Conjunctivae
E. Nictitating Membrane
F. Sclera
G. Cornea
H. Iris and Ciliary Body
I. Aqueous Humor
J. Vitreous Body
K. Orbital Cavity
L. Nasolacrimal Apparatus
M. General Cytodiagnostic Groups for Otic Cytology
N. Normal Ear Anatomy and Histology
O. External Ear Canal and Pinna
P. Otitis Media
Q. References

17. Endocrine/Neuroendocrine Systems
A. Thyroid Gland
B. Parathyroid Gland
C. Adrenal Gland
D. Chemoreceptor Tumors
E. Carcinoids
F. References

18. Advanced Diagnostic Techniques
A. Immunohistochemistry
B. Immunocytochemistry
C. Electron Microscopy
D. Special Histochemical Stains
E. Flow Cytometry
F. PCR for Antigen Receptor Rearrangements
G. Detection of Mutations, Translocations, and Copy Number Variations
H. References

Appendix 1. Microscope Equipment and Proper Usage
A. Microscope Basics
B. Using Polarized Lenses
C. Smartphone Telecytology

Appendix 2. Selected Cytologic Staining Protocols
A. Alkaline Phosphatase Stain
B. Acid-Alcohol Destaining
C. Periodic-Acid Schiff Stain
D. Gram Stain
E. Lipid Stains
F. Immunocytochemical Staining

Appendix 3. Cytologically Confusing Structures and Polarizing Materials
A. Artefactual Findings
B. Normal but Cytologically Confusing Structures
C. Polarizing Substances

Appendix 4. Mitotic Figures and Chromatin Patterns
A. Normal Mitotic Figures
B. Abnormal Mitotic Figures
C. Chromatin Patterns

Appendix 5. Advanced Collection and Preparation Techniques
A. Cell Block
B. Fluid Conversion for Histopathology
C. Cell Transfer

Appendix 6. Composing Cytologic and Histologic Reports
A. Basic cytologic terminology and cytologic report elements
B. Example fluid and solid specimen cytology descriptions
C. Basic histologic terminology and histologic report elements
D. Example infectious and neoplastic histology descriptions

Appendix 7. List of Selected Specialized Testing Sites
A. Calculi identification
B. BRAF mutation for canine bladder cancer
C. C-Kit mutation analysis
D. Endocrine
E. Flow Cytometry
F. Genetic testing for metabolic diseases
G. Immunochemistry
H. Oomycete identification
I. PARR for clonality
J. PCR for infectious agents

Appendix 8. Quick Reference for Morphologic Features of Infectious and Parasitic Agents
A. Bacteria
B. Fungi
C. Protozoa
D. Parasites

Appendix 9. Quality Assurance and Diagnostic Test Reporting
A. Quality assurance guidelines
B. Accuracy and precision related to cytology
C. Validation comparisons
D. Evidence-based cytology in practice

Book Reviews

"The book is full of colour illustrations, more than 1200 in fact, and is accompanied by a clear text. The layout of the chapters has been enormously improved compared to the first edition. Reading through the book I got very enthusiastic about its quality. This book has been very much improved from its first edition and has become one of the better ones in this field." EJCAP review, January 2010