Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set - Edition 11 - By Gary S. Firestein, MD, Ralph C. Budd, MD, Sherine E Gabriel, MD, MSc, Iain B. McInnes, PhD, FRCP, FRSE, FMedSci, James R. O'Dell, MD and Gary Koretzky, MD Elsevier Health Inspection Copies

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Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set,

Edition 11

By Gary S. Firestein, MD, Ralph C. Budd, MD, Sherine E Gabriel, MD, MSc, Iain B. McInnes, PhD, FRCP, FRSE, FMedSci, James R. O'Dell, MD and Gary Koretzky, MD

Publication Date: 28 Jul 2020

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Through 10 outstanding editions, Kelley & Firestein’s Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference.

Key Features

Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making.
Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis.
Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs.
Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology.
Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

About the author

By Gary S. Firestein, MD, Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical and Translational Research Institute, USA; Ralph C. Budd, MD, Professor of Medicine and Microbiology and Molecular Genetics, Director, Vermont Center for Immunology and Infectious Diseases, University of Vermont College of Medicine Distinguished University Professor, The University of Vermont College of Medicine, Burlington, Vermont; Sherine E Gabriel, MD, MSc, Professor and Dean, Rutgers Robert Wood Johnson Medical School, CEO, Robert Wood Johnson Medical Group, Emeritus Professor, Mayo Clinic, New Brunswick, New Jersey; Iain B. McInnes, PhD, FRCP, FRSE, FMedSci, Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; James R. O'Dell, MD, Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska, USA and Gary Koretzky, MD, Vice Dean at Weill Cornell Medical College, Frank H.T. Rhodes Distinguished Professor of Cardiovascular Biology and Genetics, USA

VOLUME I

Part 1: Structure and Function of Bone, Joints, and Connective Tissue

1. Biology of the Normal Joint, 1
Carla R. Scanzello and Steven R. Goldring

2. Synovium, 20
Douglas J. Veale and Gary S. Firestein

3. Cartilage and Chondrocytes, 34
Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser

4. Biology, Physiology, and Morphology of Bone, 60
Aline Bozec, Anika Grüneboom, and Georg Schett

5. Muscle: Anatomy, Physiology, and Biochemistry, 67
Mark S. Miller, Edward P. Debold, and Michael J. Toth

6. Biomechanics, 80
Kenton R. Kaufman and KaiNan An

7. Regenerative Medicine and Tissue Engineering, 92
Frank P. Luyten, Cosimo De Bari, and Francesco Dell’Accio

8. Proteinases and Matrix Degradation, 109
Yoshifumi Itoh

Part 2: Cells Involved in Autoimmune Diseases and Inflammation

9. Dendritic Cells, 132
Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj

10. Mononuclear Phagocytes, 149
Deborah R. Winter, Anna Montgomery, and Harris Perlman

11. Neutrophils, 161
Binita Shah, Nathalie Burg, and Michael H. Pillinger

12. T Lymphocytes, 182
Ralph C. Budd

13. B Cells, 199
Yong-Rui Zou, Christine Grimaldi, and Betty Diamond

14. Fibroblasts and Fibroblast-like Synoviocytes, 222
Christopher D. Buckley and Andrew Filer

15. Mast Cells, 241
Peter A. Nigrovic

16. Innate Lymphoid Cells and Natural Killer Cells, 254
Michael A. Paley and Wayne M. Yokoyama

17. Platelets and Megakaryocytes, 262
Eric Boilard and Peter A. Nigrovic

Part 3: Effector Mechanisms in Autoimmunity and Inflammation

18. Principles of Signaling, 273
Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos

19. The Immunologic Repercussions of Cell Death, 286
Helen M. Beere and Douglas R. Green

20. Innate Immunity, 306
Gregoire Lauvau and Steven A. Porcelli

21. Adaptive Immunity, 320
Martha S. Jordan and Gary A. Koretzky

22. Autoimmunity and Tolerance, 337
Dwight H. Kono and Argyrios N. Theofilopoulos

23. The Microbiome in Health and Disease, 355
Rob Knight

24. Metabolic Regulation of Immunity, 368
Ruoning Wang, Tingting Wang, and Stephen Tait

25. Genetics of Rheumatic Diseases, 378
Stephen Eyre and Anne Barton

26. Epigenetics of Rheumatic Diseases, 393
Amr H. Sawalha and Matlock A. Jeffries

27. Complement System, 409
V. Michael Holers and Leendert A. Trouw

28. Prostaglandins, Leukotrienes, and Related Compounds, 420
Robert B. Zurier

29. Chemokines and Cellular Recruitment, 437
Gerard Graham

30. Angiogenesis, 445
Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale

31. Cytokines, 455
Iain B. McInnes

32. Experimental Models for Rheumatoid Arthritis, 467
Rikard Holmdahl

33. Neuronal Regulation of Pain and Inflammation, 480
Camilla I. Svensson and Linda S. Sorkin

Part 4: Broad Issues in the Approach to Rheumatic Disease

34. Clinical Research Methods in Rheumatic Disease, 495
Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag

35. Economic Impact of Arthritis and Rheumatic Conditions, 510
Louise B. Murphy

36. Assessment of Health Outcomes, 522
Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell

37. Biomarkers in Rheumatology, 536
Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan

38. Occupational and Recreational Musculoskeletal Disorders, 551
Richard S. Panush

39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563
Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb

40. Cancer Risk in Rheumatic Diseases, 579
Eric L. Matteson

41. Introduction to Physical Medicine and Rehabilitation, 592
Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke

42. Pregnancy and Rheumatic Diseases, 604
Lisa R. Sammaritano and Bonnie L. Bermas

Part 5: Evaluation of Generalized and Localized Symptoms

43. History and Physical Examination of the Musculoskeletal System, 621
John M. Davis III, Kevin G. Moder, and Gene G. Hunder

44. Ultrasound in Rheumatology, 638
Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella

45. Evaluation of Monoarticular and Polyarticular Arthritis, 663
Ronald F. van Vollenhoven

46. Skin and Rheumatic Diseases, 678
David F. Fiorentino and Victoria P. Werth

47. The Eye and Rheumatic Diseases, 702
James T. Rosenbaum

Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain

48. Neck Pain, 711
Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng

49. Shoulder Pain, 727
Scott David Martin and Thomas S. Thornhill

50. Low Back Pain, 753
Rajiv Dixit

51. Hip and Knee Pain, 776
James I. Huddleston, III, and Stuart Goodman

52. Foot and Ankle Pain, 792
Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan

53. Hand and Wrist Pain, 800
Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart

54. Temporomandibular Joint Pain, 813
Daniel M. Laskin

55. Fibromyalgia, 825
Leslie J. Crofford

Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases

56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841
Hani S. El-Gabalawy and Stacy Tanner

57. Arthrocentesis and Injection of Joints and Soft Tissues, 859
Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield

58. Anti-nuclear Antibodies, 875
Stanford L. Peng and Joseph E. Craft

59. Autoantibodies in Rheumatoid Arthritis, 890
Erika Darrah, Antony Rosen, and Felipe Andrade

60. Acute Phase Reactants, 907
Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena

61.Imaging in Rheumatic Diseases, 920
Mikkel Østergaard, Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert

Part 8: Pharmacology of Anti-rheumatic Drugs

62. Therapeutic Targeting of Prostanoids, 965
Leslie J. Crofford

63. Glucocorticoid Therapy, 985
Marlies C. van der Goes and Johannes W.G. Jacobs

64. Traditional DMARDs: Methotrexate, Lefl, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 1007
Amy C. Cannella and James R. O’Dell

65. Immunosuppressive Drugs, 1031
Jacob M. van Laar

66. Anti-cytokine Therapies, 1046
Katharine McCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin

67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, 1068
Peter C. Taylor

68. Intra-cellular Targeting Agents in Rheumatic Disease, 1091
Virginia Reddy and Stanley Cohen

69. Urate-Lowering Therapy, 1111
Ted R. Mikuls

70. Bisphosphonates, 1125
Arthur C. Santora II and Kenneth G. Saag

71. Analgesic Agents in Rheumatic Disease, 1135
Gregory R. Polston and Mark S. Wallace

72. Nutrition and Rheumatic Diseases, 1156
Lisa K. Stamp and Leslie G. Cleland

73. Evaluation and Management of Early Undifferentiated Arthritis, 1173
Karim Raza

VOLUME II

Part 9: Rheumatoid Arthritis

74. Etiology of Rheumatoid Arthritis, 1181
Gary S. Firestein

75. Pathogenesis of Rheumatoid Arthritis, 1200
Gary S. Firestein

76. Clinical Features of Rheumatoid Arthritis, 1236
Bryant R. England and Ted R. Mikuls

77. Treatment of Rheumatoid Arthritis, 1258
James R. O’Dell

78. Sjögren’s Syndrome, 1284
E. William St. Clair and David L. Leverenz

Part 10: Spondyloarthritis

79. Etiology and Pathogenesis of Spondyloarthritis, 1307
Keith A. Sikora and Robert A. Colbert

80. Ankylosing Spondylitis and Other Forms of Axial Spondyloarthritis, 1319
Sjef van der Linden, Matthew Brown, Lianne S. Gensler, Tony Kenna, Walter P. Maksymowych, and William J. Taylor

81. Reactive Arthritis, 1344
John D. Carter and Alan P. Hudson

82. Psoriatic Arthritis, 1359
Oliver FitzGerald and Conor Magee

83. Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic Arthropathies, 1381
Richard Zamore, Meenakshi Bewtra, and Alexis Ogdie

Part 11: Systemic Lupus Erythematosus and Related Syndromes

84. Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1396
Mary K. Crow

85. Clinical Features of Systemic Lupus Erythematosus, 1413
Maria Dall’Era and David Wofsy

86. Treatment of Systemic Lupus Erythematosus, 1437
Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas

87. Antiphospholipid Syndrome, 1460
Medha Barbhaiya, Jane E. Salmon, and Doruk Erkan

Part 12: Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes

88. Etiology and Pathogenesis of Systemic Sclerosis, 1473
John Varga

89. Clinical Features and Treatment of Scleroderma, 1499
Fredrick M. Wigley and Francesco Boin

90. Inflammatory Diseases of Muscle and Other Myopathies, 1539
Kanneboyina Nagaraju, Rohit Aggarwal, and Ingrid E. Lundberg

91. Overlap Syndromes, 1569
Jonathan Graf

Part 13: Vasculitis

92. Classification and Epidemiology of Systemic Vasculitis, 1584
Rennie L. Rhee and Peter A. Merkel

93. Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis, 1595
David B. Hellmann

94. Anti-neutrophil Cytoplasmic Antibody– Associated Vasculitis, 1617
Sharon A. Chung and Paul A. Monach

95. Polyarteritis Nodosa and Related Disorders, 1634
Raashid Luqmani and Abid Awisat

96. Immune Complex–Mediated Small Vessel Vasculitis, 1649
John H. Stone

97. Primary Angiitis of the Central Nervous System, 1659
Rula A. Hajj-Ali and Carol A. Langford

98. Behçet’s Disease, 1666
Christine S. Ahn, Lindsay C. Strowd, and Joseph L. Jorizzo

Part 14: Crystal-Induced and Inflammasome- Mediated Inflammation

99. Pathogenesis of Inflammasome-Mediated Diseases, 1676
Hal M. Hoffman and Lori Broderick

100. Etiology and Pathogenesis of Hyperuricemia and Gout, 1687
Robert T. Keenan, Michael Toprover, and Michael H. Pillinger

101. Clinical Features and Treatment of Gout, 1710
Nicola Dalbeth

102. Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate, 1732
Robert Terkeltaub

103. Familial Autoinflammatory Syndromes, 1752
Catharina M. Mulders-Manders, Anna Simon, and Jos W.M. van der Meer

Part 15: Cartilage, Bone, and Heritable Connective Tissue Disorders

104. Pathogenesis of Osteoarthritis, 1770
Paul E. Di Cesare, Dominik R. Haudenschild, Steven B. Abramson, and Jonathan Samuels

105. Clinical Features of Osteoarthritis, 1789
Amanda E. Nelson

106. Treatment of Osteoarthritis, 1803
Devyani Misra, Deepak Kumar, and Tuhina Neogi

107. Metabolic Bone Disease, 1819
Nancy E. Lane

108. Proliferative Bone Diseases, 1839
Reuven Mader

109. Osteonecrosis, 1852
Christopher Chang, Adam Greenspan, and M. Eric Gershwin

110. Relapsing Polychondritis, 1876
Gaye Cunnane

111. Heritable Diseases of Connective Tissue, 1886
Deborah Krakow

Part 16: Rheumatic Diseases of Childhood

112. Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, 1905
Edward M. Behrens

113. Clinical Features and Treatment of Juvenile Idiopathic Arthritis, 1911
Joyce J. Hsu, Tzielan C. Lee, and Christy I. Sandborg

114. Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus, 1931
Stacy P. Ardoin and Fatima Barbar-Smiley

115.Juvenile Dermatomyositis, Scleroderma, Vasculitis, and Autoimmune Brain Disease, 1942
Angela B. Robinson, Jeffrey Dvergsten, Kathryn S. Torok, Heather Van Mater, William Gallentine, and Ann M. Reed

Part 17: Infection and Arthritis

116. Bacterial Arthritis, 1979
Paul P. Cook and Dawd S. Siraj

117. Lyme Disease, 1994
Linda K. Bockenstedt

118. Mycobacterial Infections of Bones and Joints, 2009
Eric M. Ruderman and John P. Flaherty

119. Fungal Infections of Bones and Joints, 2022
Eric M. Ruderman and John P. Flaherty

120. Rheumatic Manifestations of HIV Infection, 2033
Jonathan Dau and John D. Reveille

121. Viral Arthritis, 2048
Philippe Gasque and Xavier Guillot

122. Rheumatic Fever and Post-streptococcal Arthritis, 2061
Luiza Guilherme, Pedro Ming Azevedo, and Jorge Kalil

Part 18: Arthritis Accompanying Systemic Disease

123. Amyloidosis, 2077
Helen J. Lachmann and Faye A. Sharpley

124. Sarcoidosis, 2088
Peter Korsten, Nadera J. Sweiss, and Robert P. Baughman

125. Hemochromatosis, 2105
Gaye Cunnane

126. Hemophilic Arthropathy, 2115
Astrid E. Pulles, Lize F. D. van Vulpen, and Floris P.J.G. Lafeber

127. Rheumatic Manifestations of Hemoglobinopathies, 2127
Carlos J. Lozada and Elaine C. Tozman

128. IgG4-Related Disease, 2135
John H. Stone and Shiv Pillai

129. Arthritis Accompanying Endocrine and Metabolic Disorders, 2149
Sebastian E. Sattui and Joseph A. Markenson

130. Rheumatic Paraneoplastic Syndromes—Links Between Malignancy and Autoimmunity, 2161
Bernhard Manger and Georg Schett

131. Tumors and Tumor-like Lesions of Joints and Related Structures, 2167
Darcy A. Kerr and Andrew E. Rosenberg

132. Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer, 2189
Laura C. Cappelli, Clifton O. Bingham III, and Ami A. Shah

Index, I-1

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ISBN: 9780323639200

Page Count: 2400

Illustrations : 850 illustrations (150 in full color)

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