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Solving Problems with NMR Spectroscopy,

Edition 2

Editors: By Atta-ur Rahman, Muhammad Iqbal Choudhary and Atia-tul- Wahab

Publication Date: 04 Sep 2015

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Solving Problems with NMR Spectroscopy, Second Edition, is a fully updated and revised version of the best-selling book. This new edition still clearly presents the basic principles and applications of NMR spectroscopy with only as much math as is necessary. It shows how to solve chemical structures with NMR by giving many new, clear examples for readers to understand and try, with new solutions provided in the text. It also explains new developments and concepts in NMR spectroscopy, including sensitivity problems (hardware and software solutions) and an extension of the multidimensional coverage to 3D NMR. The book also includes a series of applications showing how NMR is used in real life to solve advanced problems beyond simple small-molecule chemical analysis. This new text enables organic chemistry students to choose the most appropriate NMR techniques to solve specific structures. The problems provided by the authors help readers understand the discussion more clearly and the solution and interpretation of spectra help readers become proficient in the application of important, modern 1D, 2D, and 3D NMR techniques to structural studies.

Key Features

Explains and presents the most important NMR techniques used for structural determinations
Offers a unique problem-solving approach for readers to understand how to solve structure problems
Uses questions and problems, including discussions of their solutions and interpretations, to help readers understand the fundamentals and applications of NMR
Avoids use of extensive mathematical formulas and clearly explains how to implement NMR structure analysis
Foreword by Nobel Prize winner Richard R. Ernst

New to This Edition

Key developments in the field of NMR spectroscopy since the First Edition in 1996
New chapter on sensitivity enhancement, a key driver of development in NMR spectroscopy
New concepts such as Pulse Field Gradients, shaped pulses, and DOSY (Diffusion Order Spectroscopy) in relevant chapters
More emphasis on practical aspects of NMR spectroscopy, such as the use of Shigemi tubes and various types of cryogenic probes
Over 100 new problems and questions addressing the key concepts in NMR spectroscopy
Improved figures and diagrams
More than 180 example problems to solve, with detailed solutions provided at the end of each chapter

About the author

By Atta-ur Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan; Muhammad Iqbal Choudhary, Professor, International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Karachi, Pakistan and Atia-tul- Wahab, Assistant Professor, Dr. Panjwani Center for Molecular Medicine and Drug Research (International Center for Chemical and Biological Sciences), University of Karachi, Karachi, Pakistan

Chapter 1: The Basics of Modern NMR Spectroscopy

Abstract
1.1. What Is NMR?
1.2. Instrumentation
Solutions to problems

Chapter 2: Creating NMR Signals

Abstract
2.1. Genesis of NMR signals
2.2. Sensitivity enhancement
2.3. Resolution Enhancement
2.4. Pulse width calibration
2.5. Phase cycling
Solutions to problems

Chapter 3: Sensitivity Enhancement

Abstract
3.1. Sensitivity problem
3.2. First milestone in the NMR sensitivity enhancement
3.3. Advances in NMR hardware for improving the sensitivity and detection
3.4. NMR tubes
3.5. Innovative processing and pulse techniques for improving the sensitivity and detection
3.6. Other methods for sensitivity enhancement
3.7. Key applications of sensitivity enhanced NMR spectroscopy
Solutions to problems

Chapter 4: Spin-Echo and Polarization Transfer

Abstract
4.1. Spin-echo formation in homonuclear and heteronuclear systems
4.2. Cross-polarization
4.3. Polarization transfer in reverse
Solutions to problems

Chapter 5: The Second Dimension

Abstract
5.1. Concept and genesis
5.2. Data acquisition in 2D NMR
5.3. Data processing in 2D NMR
5.4. Plotting of 2D spectra
Solutions to problems

Chapter 6: Nuclear Overhauser Effect

Abstract
6.1. What Is nuclear overhauser effect?
6.2. nOe and selective population transfer
6.3. Relaxation
6.4. Mechanism of nOe
6.5. Factors affecting nOe
6.6. Some practical hints
6.7. Limitations of 1D nOe methods
6.8. Two-dimensional nuclear overhauser effect spectroscopy (NOESY)
6.9. Saturation transfer difference (STD) NMR spectroscopy
Solutions to problems

Chapter 7: Important 2D NMR Experiments

Abstract
7.1. Homonuclear and heteronuclear shift-correlation spectroscopy
7.2. Homo- and heteronuclear J-resolved spectroscopy
7.3. Two-dimensional nuclear overhauser spectroscopy
7.4. Two-dimensional chemical exchange spectroscopy
7.5. Homonuclear Hartmann–Hahn spectroscopy (HOHAHA), or total correlation spectroscopy (TOCSY)
7.6. “Inverse¿ NMR spectroscopy
7.7. INADEQUATE
Solutions to problems

Chapter 8: Playing with Dimensions in NMR Spectroscopy

Abstract
8.1. Three-dimensional spectroscopy
8.2. Concatenated NMR techniques
Solution to problem

Chapter 9: Some Key Developments in NMR Spectroscopy

Abstract
9.1. Development of new hardware
9.2. Key developments in solid-state NMR spectroscopy
9.3. Innovative pulse sequences and novel applications of NMR spectroscopy

Chapter 10: Logical Approach for Solving Structural Problems

Abstract
10.1. Structure elucidation step by step
10.2. Logical protocol
10.3. Examples

Book Reviews

Praise for the first edition: "Solving Problems with NMR Spectroscopy is a very welcome addition to the existing literature. It fulfills a real need for an up-to-date and authoritatively written introduction for students and practitioners of NMR."—Richard R. Ernest, Nobel Prize in Chemistry, 1991

ISBN: 9780124115897

Page Count: 534

Retail Price :

9780080548180; 9780123849700; 9780120846627; 9780121644918

Senior and graduate chemistry students and organic, medicinal, and pharmaceutical chemists